NEW YORK — New York could be at risk of going the way of London.

As a generation of designers like Isaac Mizrahi, Todd Oldham, Stephen Sprouse and Christian Francis Rothhas disappeared from the runways for one reason or another, editors and retailers in Manhattan have turned up the pressure to find the Next Big Thing. The desperation for hype has reached such a degree that many believe the designers are being endangered with self-destruction.

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