Christmas business nationwide has been challenging, but Saturday should be a big day on Madison Avenue.

That’s when businesses along the luxury venue from 57th to 86th Streets conduct the 29th annual “Miracle on Madison Avenue” charity event. For the fourth year in a row, they will donate 20 percent of their sales on the day to The Society of Memorial Sloan Kettering Cancer Center pediatric initiatives.

“At a time when the economy has been a little difficult around the country, there is tremendous support because these businesses really care about the cause,” said Matthew Bauer, president of Madison Avenue Business Improvement District. Noting that 80 businesses are supporting the event, Bauer said, “Ralph Lauren every year has been a big supporter of Miracle on Madison Avenue, as have Michael Kors, Kate Spade, Coach, Etro, David Yurman and many other brands. They continue to come back year after year. But the event this year has also very much been embraced by some of the newest retailers on Madison Avenue including Fendi, Apple, Sanjay Kasliwal, Velvet by Graham & Spencer, L.K. Bennett and Jitrois.”

Sandra Lee of the Food Network is serving as “miracle ambassador,” Gotham Magazine is the media sponsor and Victorian-dressed holiday carolers and refreshments will be up and down the avenue, as tens of thousands of dollars are expected to be raised. Also present will be Lavinia Branca Snyder, president of The Society of Memorial Sloan Kettering Cancer Center, and MSK committee members Muffie Potter Aston, Leslie Coleman, Judy Cox, Jennifer Oken and Caryn Zucker. The event runs from 10 a.m. to 5 p.m.

The Society of MSK is a volunteer organization that raises funds for cancer research and treatment and to provide public education on the prevention, early detection and treatment of cancer. Last year, $160,000 was raised for The Society of MSK in the single day of shopping.

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