Saks Fifth Avenue’s Key to the Cure campaign is always a team effort of A-list talent from fashion and Hollywood. Now in its 18th year, the 2016 cancer research campaign will feature Halle Berry as the face of the initiative, wearing a limited-edition T-shirt designed by Christian Louboutin.

Past ambassador/designer combinations have included Julianne Moore and Jason Wu; Jennifer Aniston and Peter Dundas; Gwyneth Paltrow and Karl Lagerfeld. The 2016 campaign is the first time Saks has partnered with an accessories designer on the project.

When Saks first asked me to participate in this project I felt honored,” said Louboutin, who designed a white T-shirt with a trompe l’oeil necklace and an illustration of a pink stiletto on it, which Berry wears with ripped jeans and nude pumps in the campaign. “I consider this important and a great cause.”

The campaign breaks Oct. 1, when the T-shirt will be available for $35 at all Saks Fifth Avenue locations in U.S. and Canada as well as on and Saks has long worked with the Entertainment Industry Foundation on Key to the Cure. For the second year in a row, 100 percent of the sales of the T-shirts will benefit Stand Up to Cancer, an EIF offshoot created to fuel innovative cancer research through collaboration among leading scientists from different institutions and disciplines.

“Key to the Cure is one of the most important and valuable fund-raising and charitable initiatives that Saks undertakes,” said Marc Metrick, president of Saks Fifth Avenue. “We are committed to supporting the causes we believe in, and at almost two decades old, this annual campaign has raised close to $40 million for cancer research and treatment organizations throughout the United States. This year, we are thrilled to collaborate with SU2C for the second year in a row, as well as have the support of Halle Berry and Christian Louboutin on our extraordinary campaign to fund cancer research and treatment.”

“I, like so many others, have been touched by cancer, which is why I’m proud to continue to lend my support to the Entertainment Industry Foundation and Stand Up to Cancer in serving as this year’s Key to the Cure ambassador,” said Berry.

To support the cause, Saks hosts an annual charity shopping weekend beginning Oct. 27 at its 40 locations. Organizations which benefited from Saks Key to the Cure charity include the Breast Cancer Research Foundation, EIF’s Women’s Cancer Research Fund, Cleveland Clinic, Boston’s Dana-Farber Cancer Institute and the Nevada Cancer Institute.