Lee joins from Hearst Magazines, where she was accessories director at its fashion arm.
The charity raised $4.7 million in Culver City on Saturday night.
The second panel of the night featured Anita Patrickson, Martha Garcia, Kathy Kartalis and Bianca Gates.
The inaugural event honored Netflix’s Ted Sarandos and ambassador Nicole Avant.
Alongside the likes of Olivia Munn, Laverne Cox and Joan Smalls, the designer also celebrated the release of his self-titled book, out Nov. 12.
“There is not a human being on the planet Earth that I hold in higher regard than Robert Iger,” said Oprah Winfrey, before handing the executive the centennial award. “No one.”
From flashy headbands to multiple designer wedding gowns, “Gossip Girl” produced some of the most fashionable TV moments of the late Aughts.
Zendaya, Ian Somerhalder and Damien Chazelle also attended the Italian couturier’s show at the Petit Palais on Tuesday.
The collections encompass decor and accessories for the nursery, bedroom and playroom.
Iman, Taylor Hill, Olivia Palermo, the Shibutani siblings & more curated holiday shopping lists; Rachel Zoe and Nate Berkus hosted the event.